Schizophrenia is a chronic, severe mental illness that disrupts thinking, perception, emotions, and behavior. Symptoms include delusions, hallucinations, disorganized speech or behavior, and negative symptoms like reduced motivation or social engagement1. Onset typically occurs in late adolescence or early adulthood, with earlier presentation in males2.

Prevalence in the U.S. ranges from 0.25% to 0.64%, and while exact causes remain unclear, research points to a combination of genetic, neurodevelopmental, and environmental factors2. Diagnosis requires at least six months of symptoms with functional impairment.

Treatment relies on antipsychotic medications alongside psychosocial interventions such as cognitive behavioral therapy, family support, and case management. Coordinated specialty care improves long-term outcomes and reduces relapse risk1,3.

Primary care and behavioral health providers play a key role in early recognition, medication monitoring, and supporting continuity of care. Collaborative, team-based approaches are essential to improving recovery and quality of life.

  1. American Psychiatric Association. (2023). What is schizophrenia?
  2. National Institute of Mental Health. (n.d.). Schizophrenia
  3. World Health Organization. (2022). Schizophrenia: Key facts.

Pharmacologic Class Common Brand Names & Formulations Generic Name
Conventional Antipsychotics (First Generation)
  • Haldol
  • Haldol decanoate (q1month long-acting injectable)
Haloperidol
Conventional Antipsychotics (First Generation)
  •  Loxitane 
 Loxapine 
Conventional Antipsychotics (First Generation)
  •  Navane 
Thiothixene 
Conventional Antipsychotics (First Generation)
  • Prolixin
  • Fluphenazine Decanoate (q2-4 weeks long-acting injectable) 
 Fluphenazine 
Conventional Antipsychotics (First Generation) 
  •  Stelazine 
 Trifluoperazine 
Conventional Antipsychotics (First Generation) 
  •  Thorazine 
Chlorpromazine 
Conventional Antipsychotics (First Generation) 
  •  Trilafon  
Perphenazine
Atypical Antipsychotics (Second Generation) 
  • Abilify
  • Abilify Maintena (q1month long-acting injectable)
Aripiprazole
Atypical Antipsychotics (Second Generation)
  • Abilify Aristada (q1month long-acting injectable)
Aripiprazole lauroxil
Atypical Antipsychotics (Second Generation)
  • Caplyta
Lumateperone
Atypical Antipsychotics (Second Generation)
  • Clozaril
Clozapine
Atypical Antipsychotics (Second Generation)
  • Fanapt
Iloperidone
Atypical Antipsychotics (Second Generation)
  • Geodon
Ziprasidone
Atypical Antipsychotics (Second Generation)
  • Invega
  • Invega Sustenna (q1month long-acting injectable)
  • Invega Trinza (q3months long-acting injectable)
  • Invega Hafyera (q6month long-acting injectable)
Paliperidone
Atypical Antipsychotics (Second Generation)
  • Latuda
Lurasidone
Atypical Antipsychotics (Second Generation)
  •  Rexulti 
Brexpiprazole
Atypical Antipsychotics (Second Generation)
  • Risperdal
  • Risperdal , M-TAB (orally dissolvable tablet)
  • Risperdal Consta (q1month long-acting injectable)
Risperidone
Atypical Antipsychotics (Second Generation)
  •  Saphris 
 Asenapine 
Atypical Antipsychotics (Second Generation)
  •  Seroquel 
  •  Seroquel XR (extended release) 
 Quetiapine 
Atypical Antipsychotics (Second Generation)
  •  Vraylar 
 Cariprazine 
Atypical Antipsychotics (Second Generation)
  • Zyprexa
  • Zyprexa Zydis (orally dissolvable tablet) 
 Olanzapine 
Muscarinic Agonists & Antagonist
  •  Cobenfy 
 Xanomeline & trospium chloride